Digg.com is unique in that each page that it renders is the result of many http requests to many different servers, each which loads some widget or box on their website. They are testing a new technology (you can test it free too, see the link) that lets you basically do this through one connection, and control the order of how each request/item is loaded on the page. Interesting!

http://www.readwriteweb.com/archives/digg_demos_optimized_datastreams.php

Best Practices for Optimizing Websites by Yahoo, Really Informative, goes into detail from structuring CSS / HTML to server hosting

http://developer.yahoo.com/performance/rules.html

How to Design a Database - What to think about so you don’t run in to trouble later; set yourself up well to scale and prosper

Databases From Scratch III: The relational database design process

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